Enlarged perivascular spaces under the dorso-lateral prefrontal cortex and severity of autism.

ABSTRACT: The glymphatic system allows cerebrospinal fluid (CSF) flow along the brain's perivascular spaces (PVS), aiding in the removal of harmful substances into the venous system. Previous studies have suggested that younger males with severe autism spectrum disorder (ASD) exhibit enlarged PVS (ePVS), although the specific regions or extent of PVS enlargement remain unclear. Additionally, it is still unknown whether the localization of ePVS correlates with specific ASD symptoms. Using automated MRI-based PVS quantification, we conducted a descriptive observational study to map the number, diameter, and volume of PVS across 72 brain areas, correlating these features with the clinical severity of autism and the presence or absence of three distinct ASD symptoms: language impairment, stereotypies, a

SUBMITTER: Sotgiu S 

PROVIDER: S-EPMC11891330 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature