Association between statin administration and <i>Clostridium difficile</i>-induced enteritis: a retrospective analysis of the MIMIC-IV database.

ABSTRACT:

Background

Existing research suggests that using statins may reduce the incidence of enteritis caused by C. difficile and improve the prognosis of patients. This study aimed to explore the relation between Clostridium difficile-induced enteritis (CDE) and statin use.

Methods

Data were collected from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. Multivariate logistic regression analysis was employed to assess the impact of statin use on CDE incidence in patients in intensive care units (ICUs) and its effect on in-hospital mortality among them. The research findings were validated by performing propensity score matching (PSM), inverse probability of treatment weighting (IPTW), and subgroup analyses.

Results

The study enrolled the

SUBMITTER: Wang R 

PROVIDER: S-EPMC11891362 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature