Hydrogel and scalp/skin conductivities impact dose from tumor treating fields.

ABSTRACT:

Purpose

Tumor Treating Fields (TTFields) are delivered by transducer arrays applied to scalp or body surface for treatment of multiple malignancies. Dermatologic complications are thought to be related to hydrogel situated between the electrodes and scalp or skin to facilitate electric field penetration. High intensity of TTFields on these surfaces may also be a contributing factor. We explored conductivity changes in the hydrogel and skin to improve TTFields coverage and penetration.

Methods

Magnetic resonance imaging datasets from 12 glioblastoma patients and attenuation-corrected positron emission tomography-computed tomography datasets from 3 non-small cell lung and 2 ovarian carcinoma patients were used to segment anatomic structures. Finite element mesh models were gen

SUBMITTER: Lok E 

PROVIDER: S-EPMC11891368 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature