The role of adjuvant chemotherapy in rectal cancer: A nationwide cohort study from the Netherlands.

ABSTRACT:

Aim

Treatment of rectal cancer has improved significantly over the past decades. However, the role of adjuvant chemotherapy remains a matter of debate. The aim of this study is to evaluate the association between adjuvant chemotherapy and overall survival of patients with rectal cancer.

Method

Data from the Netherlands Cancer Registry were used to evaluate all nonmetastatic pathological node-positive patients who underwent treatment for rectal cancer during the time period 2009-2020 in the Netherlands. Patients were grouped according to whether they received adjuvant chemotherapy. Patients were further divided into three groups according to the type of preoperative treatment. Propensity score matching (PSM) was applied based on patient-related variables, tumour-related varia

SUBMITTER: Darai A 

PROVIDER: S-EPMC11891379 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature