The SQ tree sublingual immunotherapy tablet is effective and well tolerated in children-A pivotal phase III trial.

ABSTRACT:

Background

Allergic rhinitis and/or conjunctivitis (AR/C) induced by tree pollen is common and negatively impacts quality of life in children and adolescents. This phase III trial investigated the efficacy and safety of the SQ tree SLIT-tablet in a paediatric population (5-17 years) with moderate-to-severe AR/C induced by pollen from birch and trees in the birch homologous group.

Methods

Nine hundred and fifty-two subjects were randomized (1:1) to daily treatment with SQ tree SLIT-tablet or placebo for up to 52 weeks and had free access to AR/C symptom-relieving medications. The primary endpoint was the average total combined score (TCS); sum of average daily symptom score (DSS) and average daily medication score (DMS) during the birch pollen season (BPS). Key secondary endp

SUBMITTER: Gappa M 

PROVIDER: S-EPMC11891417 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature