Progranulin derivative attenuates lung neutrophilic infiltration from diesel exhaust particle exposure.

ABSTRACT:

Background

Air pollutants, such as diesel exhaust particles (DEPs), induce respiratory disease exacerbation with neutrophilic infiltration. Progranulin (PGRN), an epithelial cell and macrophage-derived secretory protein, is associated with neutrophilic inflammation. PGRN is digested into various derivatives at inflammatory sites and is involved in several inflammatory processes. PGRN and its derivatives likely regulate responses to DEP exposure in allergic airway inflammation.

Aim

To investigate the role of PGRN and its derivatives in the regulation of responses to DEP exposure in allergic airway inflammation.

Methods

A murine model of allergic airway inflammation was generated in PGRN-deficient mice, and they were simultaneously exposed to DEP followed by intranasal

SUBMITTER: Lee AR 

PROVIDER: S-EPMC11891434 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature