Synthesis and crystal structures of five fluorinated diphenidine derivatives.

ABSTRACT: Diphenidine (1a), a dissociative anaesthetic, was first reported in 2013. Since then, a number of derivatives e.g. 2-methoxphenidine (1b) have been produced by clandestine laboratories and sold as research chemicals. Fluorinated diphenidines, namely, [1-(2,6-di-fluoro-phen-yl)-2-phenyl-eth-yl]di-methyl-aza-nium chloride, C₁₆H₁₈F₂N⁺·Cl^-, (I), [1-(2,6-di-fluoro-phen-yl)-2-phenyl-eth-yl](eth-yl)aza-nium chloride di-chloro-methane hemisolvate, 2C₁₆H₁₈F₂N⁺·2Cl^-·CH₂Cl₂, (II), tert-but-yl[1-(2,6-di-fluoro-phen-yl)-2-phenyl-eth-yl]aza-nium chloride, C₁₈H₂₂F₂N⁺·Cl^-,

SUBMITTER: Mewis RE 

PROVIDER: S-EPMC11891590 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature