Inter-organ correlations in inflammation regulation: a novel biological paradigm in a murine model.

ABSTRACT: Interactions between immune system constituents are mediated through direct contact or the transfer of mediators. The study aimed to assess the correlation between system components and out-of-body signals in a model of liver inflammation. In the first experiment, mice injected with Concanavalin A (ConA) were housed in a cage with a tube on top containing healthy livers or livers harvested from mice injected with ConA. In the second experiment, mice were housed in a cage with a tube that contained splenocytes harvested from naïve donors or from naïve donors treated in vitro with dexamethasone. Mice were tested for serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. External whole livers and spleens influenced the immune-mediated inflammatory response of mice.

SUBMITTER: Shabat Y 

PROVIDER: S-EPMC11891616 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature