Chestnut (<i>Castanea crenata</i> S. et Z.) inner shell-A by-product promotes anti-obesity by regulating adipogenesis and lipogenesis-related genes and the AMPK/ACC signaling pathway in high-fat diet-induced obese mice.

ABSTRACT: A by-product is a secondary substance unintentionally produced during manufacturing and can be repurposed through recycling. In particular, by-products generated from the processing of natural materials are valuable because of their bioactive compound content, such as polyphenols and anthocyanins. Obesity is a global health issue, and medicines for obesity have side effects, such as insomnia and headaches. The demand for safe anti-obesity treatments based on natural products has increased. In this study, the anti-obesity efficacy of chestnut inner skin powder (CIS), a by-product, was investigated in a high-fat diet (HFD)-induced obesity model. CIS (100, 500, and 1000 mg/kg) was administered orally for 7 weeks, and 200 mg/kg garcinia was used as the positive control. Body weight (BW) and fo

SUBMITTER: Park YM 

PROVIDER: S-EPMC11891676 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature