Characterization of the immune cell infiltration patterns in lung adenocarcinoma to facilitate immunotherapy.

ABSTRACT: Although Immunotherapy has emerged as an efficient treatment in lung carcinoma, merely a subset of lung adenocarcinoma (LUAD) patients could be benefited from it. Increasing evidence revealed that tumor immune cell infiltrating (ICI) in the tumor microenvironment (TME) is highly related to patient prognosis and characteristics of the tumor. Thus far, the immune cell infiltration patterns of LUAD remain unclear. Herein, ESTIMATE and CIBERSORT algorithms were conducted to characterize the ICI patterns of 1155 patients with LUAD. Three ICI subtypes were determined, and the ICI score was constructed by performing PCA. A high ICI score group referred to increased activation of the signaling pathways related to immune activation and drug metabolism, reduced tumor mutation burden (TMB), as well a

SUBMITTER: Li H 

PROVIDER: S-EPMC11891687 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature