Unveiling functional module associated with fungal disease stress in barley (<i>Hordeum vulgare</i>).

ABSTRACT: Fungal infections pose a considerable threat to the cultivation of barley (Hordeum vulgare) and often limit the crop yield. During infection, the transcriptome undergoes extensive reprogramming involving several regulatory pathways. To address this complexity, we performed a comprehensive meta-analysis and co-expression network analysis using rigorously curated RNA-seq datasets from three different fungal diseases. Pre-processing of the data, including batch effect correction, ensured high-quality integration of the datasets. Module-trait relationship (MTR) analysis identified functional modules associated with fungal disease response. Hub genes within these modules were prioritized by multi-model centrality analyses using Cytoscape, which considered the metrics Degree, Closeness, B

SUBMITTER: Panahi B 

PROVIDER: S-EPMC11891694 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature