A novel signature predicts prognosis in pancreatic cancer based on tumor membrane-associated genes.

ABSTRACT:

Background

Pancreatic cancer is one of the leading causes of tumor-related mortality, characterized by short patient survival times and limited treatment options. Some targeted therapies have not succeeded in improving patient prognosis. Tumor membranes possess potential target specificity, offering hope for enhancing the efficacy of immunotherapy and drug treatment.

Methods

In this study, we collected gene expression and survival data from two scRNA-seq projects and patient cohorts in TCGA, ICGC, and GEO. Differential analysis and dimensionality reduction clustering were employed to isolate tumor epithelial cells. High-expression membrane-associated genes in tumor epithelial cells were identified through PPI network analysis and functional enrichment. Subsequently, membrane

SUBMITTER: Ding Z 

PROVIDER: S-EPMC11891719 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature