In Vitro and In Vivo Radiotoxicity and Biodistribution of Thallium-201 Delivered to Cancer Cells by Prussian Blue Nanoparticles.

ABSTRACT: Thallium-201 (t_1/2 = 73 h) emits around 37 Auger and other secondary electrons per decay and is highly radiotoxic when internalized into cancer cells. However, the lack of effective chelators hinders its application in molecular radiotherapy. This study evaluates Prussian blue nanoparticles, coated with citric acid (²⁰¹Tl-caPBNPs) or chitosan (²⁰¹Tl-chPBNPs), as a ²⁰¹Tl delivery vehicle compared with unbound ²⁰¹Tl⁺. Cellular uptake and efflux kinetics and radiotoxicity using clonogenic and γH2AX DNA damage assays were evaluated in vitro for both nanoparticle types. Subcellular localization was also assessed using electron microscopy with energy-dispersive X-ray spectroscopy. Biodistribution of ²⁰¹Tl-chPBNPs

SUBMITTER: Wulfmeier KM 

PROVIDER: S-EPMC11891825 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature