Silk Fibroin Surface Engineering Using Phase Separation Approaches for Enhanced Cell Adhesion and Proliferation.

ABSTRACT: Due to excellent mechanical properties and biocompatibility, materials based on silk fibroin are increasingly included in advanced biomedical research and applications. However, their poor supporting properties for cell adhesion and proliferation represent limiting factors of the utilization. To eliminate this deficiency, we developed a series of phase-separation approaches allowing for tunable texturing of planar and 3D printed fibroin surfaces from nano to macro levels. The formation of surface structures presented is based on a combination of good and poor solvents, whereas no potentially problematic templates or additives, diminishing biocompatibility of the resulting material, are required. A critical factor in obtaining and scaling of the textures is control over the degree of transf

SUBMITTER: Kocourkova K 

PROVIDER: S-EPMC11891832 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature