Ni(ii)/spiroBox-catalyzed asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes.

ABSTRACT: Nickel complexes of chiral spiroBox ligand catalyzed Friedel-Crafts alkylation reaction of indoles with nitroalkenes. Excellent yields (up to 99%) and enantiomeric excess (ee) values (up to 97%) were obtained with a broad scope of substrates. This catalytic system provides a facile synthesis of optically active 2-indolyl-1-nitro derivatives with high yield and enantioselectivity.

SUBMITTER: Li Y 

PROVIDER: S-EPMC11891994 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature