Association between serum levels of insulin-like growth factor-binding proteins at admission and outcomes at 3 months after acute ischemic stroke.

ABSTRACT:

Background

Insulin-like growth factor-binding proteins (IGFBPs) contribute to central nervous system development and may influence recovery after stroke. This study aimed to determine whether serum IGFBPs levels in acute ischemic stroke (AIS) patients are associated with 3-month outcomes.

Materials and methods

We retrospectively reviewed data from AIS patients admitted within 24 h after stroke onset, and who had been prospectively enrolled in the Chengdu Stroke Registry. Serum IGFBPs 4, 6 and 7 levels at admission were compared between patients experienced good outcome (modified Rankin Scale scores of 0-2) or poor outcome (scores of 3-6) at 3 months after stroke onset. Factors associated with good outcome were identified using logistic regression.

Results

Among 194 pa

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC11892070 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature