Pregestational Diabetes and Adverse Pregnancy Results: A Mendelian Randomization Study.

ABSTRACT:

Background

Hyperglycemia in pregnancy is believed to be associated with negative pregnancy outcomes. However, establishing a causal connection between diabetes mellitus (DM) and adverse pregnancy results is challenging due to the limitations inherent in traditional observational studies.

Methods

Our study used a two-sample Mendelian randomization (MR) technique to examine the possible influence of pregestational diabetes mellitus (PGDM) on adverse pregnancy outcomes. Summary-level data were obtained from genome-wide association studies (GWAS) of European ancestry and FinnGen biobank. The primary analysis employed the random-effects multiplicative inverse variance weighted (IVW) technique to appraise causal relationships between PGDM and adverse outcomes. Heterogeneity and pl

SUBMITTER: Hantoushzadeh S 

PROVIDER: S-EPMC11892093 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature