Single-cell transcriptome analysis reveals cellular heterogeneity in the aortas of Takayasu arteritis.

ABSTRACT:

Objectives

Takayasu arteritis (TAK) is an inflammatory vasculitis that affects the aorta and its primary branches. The pathogenesis of TAK remains elusive, yet identifying key cell types in the aorta of TAK patients is crucial for uncovering cellular heterogeneity and discovering potential therapeutic targets.

Methods

This study utilized single-cell transcriptome analysis on aortic specimens from three TAK patients, with control data sourced from a publicly available database (GSE155468). Additionally, bulk RNA sequencing was performed on peripheral CD4 + and CD8 + T cells from eight TAK patients and eight matched healthy volunteers. All participants were recruited at Anzhen Hospital, Capital Medical University, China, between January 2020 and December 2023.

Results

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SUBMITTER: Gao N 

PROVIDER: S-EPMC11892157 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature