A rapid ecologic analysis, confirmed by a case-control study, identifies class I HLA alleles correlated to the risk of COVID-19.

ABSTRACT:

Background

Several studies suggest that the heterogeneous spread of SARS-CoV-2 pandemics started on December 2019 could be partially upheld by the prevalence of permissive class I HLA alleles in specific populations. Such HLA alleles are in fact unable to shape an efficient anti-viral immune-response in the hosts or sustain an exaggerated inflammatory T cell mediated response responsible for the COVID-19 disease. We previously reported an ecologic correlation between the risk of COVID-19 spreading across Italy and the germinal expression of permissive HLA-C*01 and -B*44 alleles in specific inter and intraregional populations along the first spreading wave.

Methods

Considering that SARS-CoV-2 has undergone multiple adaptative mutations since the beginning of pandemics related

SUBMITTER: Correale P 

PROVIDER: S-EPMC11892203 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature