Trajectories of pharmacological therapies for treatment-resistant depression: a longitudinal study.

ABSTRACT:

Background

Treatment-resistant depression (TRD) in major depressive disorder (MDD) is defined as the failure of two or more antidepressants. Few studies have characterized the natural history and treatment patterns of these patients. This study aims to identify the natural history of disease and treatment trajectories for patients with TRD.

Methods

A retrospective longitudinal study used claims data linked to electronic health records (EHRs) from January 1, 2017, to October 31, 2021. Inclusion criteria were age ≥ 18 years, ≥ 1 MDD diagnosis, no antidepressant use at baseline, and an index date within 90 days of MDD diagnosis. Exclusions included psychiatric disorders other than MDD. TRD patients were defined as receiving third-line antidepressant treatment within two years o

SUBMITTER: DiBello JR 

PROVIDER: S-EPMC11892204 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature