Transcriptomic analysis revealed ferroptosis in ducklings with splenic necrosis induced by NDRV infection.

ABSTRACT: Infection with novel duck reovirus (NDRV) results in severe splenic necrosis, leading to immunosuppression, secondary infections with other pathogens, and impairment of the immune effect of the vaccine. However, little is known about NDRV-induced spleen injury and its antagonistic mechanism on the host immune response. In this study, we conducted pathological and comparative transcriptomic analyses of NDRV-infected duck spleens. Our findings elucidated the histopathological progression of splenic necrotic foci formation following NDRV infection and identified splenic macrophages as the primary target cells. RNA-Seq analysis revealed differentially expressed genes that were enriched predominantly in immune system processes, signalling molecules and interactions, and pathways related to cell

SUBMITTER: Wang H 

PROVIDER: S-EPMC11892222 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature