Extraction of a stromal metastatic gene signature in breast cancer via spatial profiling.

ABSTRACT:

Background

The identification of molecular features characterizing metastatic disease is a critical area of oncology research, as metastatic foci often exhibit distinct biological behaviors compared to primary tumors. While the focus has largely been on the neoplastic cells themselves, the characterization of the associated stroma remains largely underexplored, with significant implications for understanding metastasis.

Main body

By employing spatially resolved transcriptomics, we analyzed the transcriptional features of primary breast adenocarcinoma and its associated metastatic foci, on a representative set of microregions. We identified a stromal metastatic (Met) signature, which was subsequently validated across transcriptomic reference human breast cancer (BC) datasets

SUBMITTER: Bertolazzi G 

PROVIDER: S-EPMC11892262 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature