Fluoridated silver nanocomposites for caries management: an in-vitro assessment of the cytological and antibacterial profiles.

ABSTRACT:

Background

Silver nanoparticles (AgNPs) have antibacterial properties with potential applications in managing dental caries. Functionalization with fluoride may further enhance AgNPs' antibacterial efficacy. This study evaluated the impact of fluoridated AgNPs coated with various surface moieties on their safety profile and antibacterial effects against cariogenic bacteria as a potential anti-cariogenic treatment.

Methods

AgNP synthesis followed citrate and gallic acid reduction methods with polyethylene glycol (PEG) and polyvinylpyrrolidone coating. Functionalizing AgNPs with sodium fluoride (NaF) proceeded. Testing the safety of synthesized compounds was done on human gingival fibroblasts and oral epithelial cells. Meanwhile, minimum inhibitory concentration (MIC) determin

SUBMITTER: Essawy MM 

PROVIDER: S-EPMC11892278 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature