Prognostic significance of miR-378 in cancers: a meta-analysis.

ABSTRACT:

Background

The prognostic significance of miR-378 in cancers remains controversial. We carried out the meta-analysis to clarify the issue.

Methods

Related researches were obtained from PubMed, Web of Science and EMBASE. The search was conducted up until 10 September 2023. Hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to access the correlation between miR-378 and survival outcomes and clinicopathological features.

Results

16 articles were included in the meta-analysis. The pooled analysis showed that low miR-378 expression predicted poor overall survival (OS) (HR: 1.73, 95% CI: 1.09-2.74). No significant difference was discovered between low miR-378 expression and disease-free survival/ recurrence-free survival (DFS/RFS) (

SUBMITTER: Shi L 

PROVIDER: S-EPMC11892288 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature