Development and validation of potential molecular subtypes and signatures of thyroid eye disease based on angiogenesis-related gene analysis.

ABSTRACT:

Background

Thyroid eye disease (TED) is an autoimmune inflammatory disorder of the orbit, associated with a range of potential clinical sequelae. Tumor cells in TED overexpress pro-angiogenic factors, driving the formation of heterogeneous and immature neovascularization. This dysregulated angiogenesis often leads to a hypoxic microenvironment due to insufficient perfusion. Despite its importance, the role of angiogenesis-related genes (ARGs) in TED pathophysiology remains poorly understood.

Methods

To bridge this knowledge gap, our study aimed to identify and validate ARGs implicated in TED using a comprehensive bioinformatics strategy. By intersecting differential gene expression analyses with a curated list of 103 known ARGs, we aimed to pinpoint those with potential role

SUBMITTER: Wu Z 

PROVIDER: S-EPMC11892296 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature