Platelet hitchhiking vascular-disrupting agents for self-amplified tumor-targeting therapy.

ABSTRACT: The vascular-disrupting agent DMXAA (5,6-dimethylxanthone-4-acetic acid) exhibits potent anticancer activity by targeting tumor vasculature and activating immune responses via the cGAS-STING pathway. However, its clinical application is hindered by nonspecific targeting and significant cardiovascular toxicity. This study introduces a novel self-amplified tumor-targeting delivery system(P@NPPD)comprising azide-functionalized poly(ethylene glycol)-b-poly-[(N-2-hydroxyethyl)-aspartamide]-DMXAA (N₃-PEG-b-PHEA-DMXAA, NPPD) conjugated to DBCO modified platelets. Among them, NPPD was synthesized by conjugating DMXAA to N₃-PEG-b-poly-[(N-2-hydroxyethyl)-aspartamide] through esterification. This system enhances tumor-specific drug delivery while minimizing systemic toxicity. L

SUBMITTER: Chu H 

PROVIDER: S-EPMC11892306 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature