Impact of GLP-1RA on the Risk of Adverse Liver Outcomes Among Patients With Alcohol-Associated Liver Disease and Type 2 Diabetes.

ABSTRACT:

Background and aims

We sought to characterise the impact of GLP-1RA on adverse liver outcomes (ALO) among patients with alcohol-associated liver disease (ALD) and Type 2 diabetes mellitus (T2DM).

Methods

Patients with T2DM newly diagnosed with ALD between 2013 and 2020 were identified using IBM MarketScan database and were categorised by GLP-1RA exposure. Overlap propensity score weighting (OPSW) followed by Poisson regression models was used to analyse adjusted risk of ALO, a composite endpoint defined by first occurrence of hepatic decompensation (HD), portal hypertension (PH), hepatocellular carcinoma (HCC) or liver transplantation (LT) relative to GLP-1RA.

Results

Among 14 730 patients, most individuals were male (n = 9752, 66.2%) with median age of 57 (IQR 52-61)

SUBMITTER: Rashid Z 

PROVIDER: S-EPMC11892336 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature