Food choice and neural reward systems in adolescents with anorexia nervosa and atypical anorexia nervosa.

ABSTRACT:

Background

Adolescence is a critical developmental period for the study of anorexia nervosa (AN), an illness characterized by extreme restriction of food intake. The maturation of the reward system during adolescence combined with recent neurobiological models of AN led to the hypothesis that early on in illness, restrictive food choices would be associated with activity in nucleus accumbens reward regions, rather than caudate regions identified among adults with AN.

Methods

Healthy adolescents (HC, n = 41) and adolescents with AN or atypical AN (atypAN, n = 76) completed a Food Choice Task during fMRI scanning. Selection of high-fat foods and choice-related activation in nucleus accumbens and anterior caudate regions-of-interest (ROIs) were compared between individuals with

SUBMITTER: Lloyd EC 

PROVIDER: S-EPMC11892378 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature