Obesity drives dysregulation in DC responses to viral infection.

ABSTRACT:

Introduction

Obesity is a worldwide epidemic, with over 1 billion people worldwide living with obesity. It is associated with an increased risk of over 200 chronic co-morbidities, including an increased susceptibility to infection. Numerous studies have highlighted the dysfunction caused by obesity on a wide range of immune cell subsets, including dendritic cells (DCs). DCs are innate immune sentinels that bridge the innate and adaptive immune systems. DCs provide critical signals that instruct and shape the immune response. Our group has previously reported that DCs from people with obesity display defective cytokine production; however, the mechanisms underpinning these defects are unclear.

Methods

We investigated the functional responses of DCs using a murine-specific sin

SUBMITTER: Woodcock A 

PROVIDER: S-EPMC11892430 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature