One-Month-Old Rabbits Exhibit a Longer Postoperative Remodeling in Extraocular Muscles Compared to 3-Month-Old Rabbits.

ABSTRACT:

Purpose

To explore whether there is a difference in postoperative extraocular muscle (EOM) remodeling between 1-month-old and 3-month-old rabbits.

Methods

Recession (n = 16) and resection (n = 16) were performed on the right superior rectus (SR) muscles of 1-month-old and 3-month-old rabbits. SR tissues were harvested 1 and 4 weeks post-surgery (n = 4 for each group), and mid-belly sections were used to assess myosin heavy chain (MyHC) isoform expression (fast 2X, embryonic, and neonatal MyHCs), activated satellite cells (SCs), and centrally nucleated myofibers. Age-matched unoperated rabbits (n = 4) served as controls.

Results

In 1-month-old rabbits, fast 2X-MyHC expression continuously decreased post-recession (all P < 0.01), and embryonic MyHC expression increased

SUBMITTER: Lou J 

PROVIDER: S-EPMC11892532 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature