Phenotyping Using Polysomnography Attributes Reduced Respiratory Events after Continuous Positive Airway Pressure Therapy to Improved Upper Airway Collapsibility.

ABSTRACT: Rationale: In patients with obstructive sleep apnea (OSA) treated with continuous positive airway pressure (CPAP), the apnea-hypopnea index (AHI) measured off CPAP may be decreased relative to baseline AHI preceding CPAP treatment. Semiinvasive "endophenotyping" sleep studies attribute this fall in AHI primarily to improved ventilatory control stability. Phenotyping Using Polysomnography (PUP) attempts to reproduce these studies using routine polysomnography (PSG). Objectives: To determine whether changes in AHI after CPAP associate primarily with changes in PUP-estimated ventilatory control stability (loop gain with a 1-minute cycle time [LG₁]) or with changes in other PUP-estimated pathophysiologic mechanisms. Methods: PUP analyses were performed on

SUBMITTER: Tolbert TM 

PROVIDER: S-EPMC11892672 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature