Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer.

ABSTRACT: Cancer cells frequently alter their lipids to grow and adapt to their environment^1-3. Despite the critical functions of lipid metabolism in membrane physiology, signalling and energy production, how specific lipids contribute to tumorigenesis remains incompletely understood. Here, using functional genomics and lipidomic approaches, we identified de novo sphingolipid synthesis as an essential pathway for cancer immune evasion. Synthesis of sphingolipids is surprisingly dispensable for cancer cell proliferation in culture or in immunodeficient mice but required for tumour growth in multiple syngeneic models. Blocking sphingolipid production in cancer cells enhances the anti-proliferative effects of natural killer and CD8⁺ T cells partly via interferon-γ (IFNγ) signallin

SUBMITTER: Soula M 

PROVIDER: S-EPMC11892728 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature