Dipeptidyl Peptidase-4 Inhibitors: A Systematic Review of Structure-Activity Relationship Studies.

ABSTRACT:

Context

Dipeptidyl peptidase 4 (DPP-4) is a serine exopeptidase enzyme that hydrolyzes the amide bond at the N-terminal of peptides. This enzyme converts incretins, such as glucagon-like peptide I and glucose-dependent insulinotropic peptide, into their inactive forms, thereby preventing them from stimulating insulin secretion. Numerous studies have confirmed the role of DPP-4 in the pathophysiology of type 2 diabetes, leading to the development of various DPP-4 inhibitors. In recent years, research on DPP-4 inhibitors has expanded significantly, resulting in the creation of both non-peptidomimetic heterocyclic compounds and peptidomimetic scaffolds.

Evidence acquisition

This systematic review summarizes all recent advances related to DPP-4 inhibitors up to 2024. It begins b

SUBMITTER: Bayanati M 

PROVIDER: S-EPMC11892788 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature