Response to clopidogrel in patients undergoing lower extremity revascularization.

ABSTRACT:

Objectives

Clopidogrel is effective at decreasing cardiovascular events in patients with peripheral artery disease (PAD); however, its effect on limb outcomes are less known. This study investigated the variability in response to clopidogrel and its relationship with clinical limb outcomes.

Methods

Three hundred subjects were enrolled in the Platelet Activity and Cardiovascular Events (PACE) study prior to lower extremity revascularization, of whom 104 were on clopidogrel. Light transmission platelet aggregation was measured in response to ADP 2 μm immediately prior to revascularization. Patients were followed longitudinally for a median follow-up of 18 months. The primary endpoint was major adverse limb events (MALE) defined by major amputation or reoperation of the affecte

SUBMITTER: Tawil M 

PROVIDER: S-EPMC11892801 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature