Exploring the role of acylated ghrelin and gut microbiome in delineating cognitive health in the elderly.

ABSTRACT:

Introduction

With increased life expectancy, there is an increase in aging population and prevalence of dementia. Ghrelin is a key regulator of spatial memory and cognition. The gut microbiome may affect the circulating levels of unacylated ghrelin (UAG) and acylated ghrelin (AG). Thus, we explore the potential association of the gut microbiome, AG, and cognitive health in the aging dementia patient.

Methods

40 dementia patients and 40 controls were recruited. Fecal Microbiome analysis using 16S rRNA sequencing was performed on 18 samples. A mixed-method approach was employed for robust interpretation.

Results

Dementia patients had an increased serum AG and AG/UAG ratio. With the increase in AG among dementia subjects, a significant decrease in species richness was ob

SUBMITTER: Rout S 

PROVIDER: S-EPMC11892914 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature