Exposome-wide association study of environmental chemical exposures and epigenetic aging in the national health and nutrition examination survey.

ABSTRACT: Epigenetic clocks can serve as pivotal biomarkers linking environmental exposures with biological aging. However, research on the influence of environmental exposures on epigenetic aging has largely been limited to a small number of chemicals and specific populations. We harnessed data from the National Health and Nutrition Examination Survey 1999-2000 and 2001-2002 cycles to examine exposome-wide associations between environmental exposures and epigenetic aging. A total of 8 epigenetic aging biomarkers were obtained from whole blood in 2,346 participants ranging from 50-84 years of age. A total of 64 environmental exposures including phthalates, metals, pesticides, dioxins, and polychlorinated biphenyls (PCBs) were measured in blood and urine. Associations between log₂-transfor

SUBMITTER: Khodasevich D 

PROVIDER: S-EPMC11892924 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature