Genomic and proteomic analyses of Nus-dependent non-lambdoid phages reveal a novel coliphage group prevalent in gut: mEp_immI.

ABSTRACT:

Introduction

Nus-dependent Mexican Escherichia coli phages (mEp) were previously isolated from clinical samples of human feces. Approximately 50% corresponded to non-lambdoid temperate phages integrating a single immunity group, namely immunity I (mEp_immI), and these were as prevalent as the lambdoid phages identified in such collection.

Methods

In this work, we present the structural and functional characterization of six representative mEp_immI phages (mEp010, mEp013, mEp021, mEp044, mEp515, and mEp554). In addition, we searched for homologous phages and prophages in the GenBank sequence database, and performed extensive phylogenetic analyses on the compiled genomes.

Results

A biological feature-based characterization of these phages was

SUBMITTER: Negrete-Mendez H 

PROVIDER: S-EPMC11893012 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature