Time-efficient, high-resolution 3T whole-brain relaxometry using Cartesian 3D MR Spin TomogrAphy in Time-Domain (MR-STAT) with cerebrospinal fluid suppression.

ABSTRACT:

Purpose

Current three-dimensional (3D) MR Spin TomogrAphy in Time-Domain (MR-STAT) protocols use transient-state, gradient-spoiled gradient-echo sequences that are prone to cerebrospinal fluid (CSF) pulsation artifacts when applied to the brain. This study aims to develop a 3D MR-STAT protocol for whole-brain relaxometry that overcomes the challenges posed by CSF-induced ghosting artifacts.

Method

We optimized the flip-angle train within the Cartesian 3D MR-STAT framework to achieve two objectives: (1) minimization of the noise level in the reconstructed quantitative maps, and (2) reduction of the CSF-to-white-matter signal ratio to suppress CSF-associated pulsation artifacts. The optimized new sequence was tested on a gel/water phantom for accuracy evaluation of the quantit

SUBMITTER: Liu H 

PROVIDER: S-EPMC11893030 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature