Noninvasive blood-brain barrier integrity mapping in patients with high-grade glioma and metastasis by multi-echo time-encoded arterial spin labeling.

ABSTRACT:

Purpose

In brain tumors, disruption of the blood-brain barrier (BBB) indicates malignancy. Clinical assessment is qualitative; quantitative evaluation is feasible using the K₂ leakage parameter from dynamic susceptibility contrast MRI. However, contrast agent-based techniques are limited in patients with renal dysfunction and insensitive to subtle impairments. Assessing water transport times across the BBB (T_ex) by multi-echo arterial spin labeling promises to detect BBB impairments noninvasively and potentially more sensitively. We hypothesized that reduced T_ex indicates impaired BBB. Furthermore, we assumed higher sensitivity for T_ex than dynamic susceptibility contrast-based K₂, because arterial spin labeling uses water as a

SUBMITTER: Hoffmann G 

PROVIDER: S-EPMC11893035 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature