Investigation of diffusion time dependence of apparent diffusion coefficient and intravoxel incoherent motion parameters in the human kidney.

ABSTRACT:

Purpose

To characterize the diffusion time (Δ_eff) dependence of apparent diffusion coefficient (ADC) and intravoxel incoherent motion-related parameters in the human kidney at 3 T.

Methods

Sixteen healthy volunteers underwent an MRI examination at 3 T including diffusion-weighted imaging at different Δ_eff ranging from 24.1 to 104.1 ms. The extended mono-exponential ADC and intravoxel incoherent motion models were fitted to the data for each Δ_eff and the medullary and cortical ADC, (pseudo-)diffusion coefficients (D* and D) and flow-related signal fraction (f) were calculated.

Results

When all the data were used for fitting, a significant trend toward higher ADC with increasing Δ_eff was observed between 24.1 and 104.1 ms (med

SUBMITTER: Stabinska J 

PROVIDER: S-EPMC11893038 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature