3D deuterium metabolic imaging (DMI) of the human liver at 7 T using low-rank and subspace model-based reconstruction.

ABSTRACT:

Purpose

To implement a low-rank and subspace model-based reconstruction for 3D deuterium metabolic imaging (DMI) and compare its performance against Fourier transform-based (FFT) reconstruction in terms of spectral fitting reliability.

Methods

Both reconstruction methods were applied on simulated and experimental DMI data. Numerical simulations were performed to evaluate the effect of increasing acceleration factors. The impact on spectral fitting results, SNR, and the overall normalized root mean square error (NRMSE) compared to ground-truth data were calculated. A comparative analysis was performed on DMI data acquired from the human liver, including both natural abundance and post-deuterated glucose intake data at 7 T.

Results

Simulation showed the Cramer-Rao lower

SUBMITTER: Nam KM 

PROVIDER: S-EPMC11893041 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature