Cardiac sympathetic denervation and anxiety in Parkinson disease.

ABSTRACT:

Background

Anxiety in Parkinson disease (PD) negatively impacts quality of life. While research predominantly focuses on central nervous system changes, some evidence suggests a connection between peripheral autonomic dysfunctions and PD-related anxiety. The role of the peripheral autonomic nervous system in this context may be overlooked.

Objectives

This study explores the link between anxiety symptoms and cardiac sympathetic denervation in PD using ¹¹C-meta-hydroxyephedrine ([¹¹C]HED) PET cardiac imaging.

Methods

We studied 34 non-demented PD subjects, assessing anxiety levels through the Spielberg Anxiety State-Trait test trait section (STAI-T). Patients underwent comprehensive assessments along with [¹¹C]HED cardiac and [¹¹

SUBMITTER: Carli G 

PROVIDER: S-EPMC11893108 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature