LC-MS analysis and antioxidant, antibacterial, and antidiabetic activity of Jumli Marshi rice from Nepal: An in vitro and in silico investigation to validate their potential as a functional food.

ABSTRACT: Jumli Marshi (J. Marshi), a native rice cultivar in Nepal, is gaining popularity owing to its health benefits for obesity, hypertension, and diabetes. However, scientific evidence verifying its therapeutic potential is lacking until November 2024. Therefore, we aimed to characterize the phytoconstituents and evaluate the antioxidant, antibacterial, and antidiabetic properties of J. Marshi, along with its ADME toxicity profile, using both in vitro and in silico approaches. Liquid chromatography-mass spectrometry analysis of a 70% methanol extract from J. Marshi identified ten plant-based compounds, including phenolic acids, flavonoids, and γ-oryzanol. The extract exhibited significant antioxidant properties, neutralizing DPPH free radicals with a fifty-percentage inhibitory concentration (I

SUBMITTER: Yadav RK 

PROVIDER: S-EPMC11893129 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature