Clinical and intracranial electrophysiological signatures of post-operative and post-ictal delirium.

ABSTRACT:

Objectives

(1) Gain insight into the mechanisms of postoperative delirium (POD). (2) Determine mechanistic overlap with post-ictal delirium (PID). Epilepsy patients undergoing intracranial electrophysiological monitoring can experience both POD and PID, and thus are suitable subjects for these investigations.

Methods

POD was assessed daily after surgery. PID was assessed following seizures. Resting state data were collected following delirium assessments, during a control period, and during sleep. Slow-wave activity (SWA: 1-4 Hz) and resting state functional connectivity were compared between different time points and according to delirium status.

Results

POD was present in 6 of 20 participants. Post-operatively, SWA was globally elevated in all participants but highe

SUBMITTER: Banks MI 

PROVIDER: S-EPMC11893240 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature