Supersulfides contribute to joint homeostasis and bone regeneration.

ABSTRACT: The physiological functions of supersulfides, inorganic and organic sulfides with sulfur catenation, have been extensively studied. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal cysteine persulfide synthase. This study aimed to investigate the role of supersulfides in joint homeostasis and bone regeneration. Using Cars2^AINK/+ mutant mice, in which the KIIK motif of CARS2 essential for supersulfide production was replaced with AINK, we evaluated the role of supersulfides in fracture healing and cartilage homeostasis during osteoarthritis (OA). Tibial fracture surgery was performed on the wild-type (Cars2^+/+) and Cars2^AINK/+ mice littermates. Bulk RNA-seq analysis for the osteochondral rege

SUBMITTER: Maemura M 

PROVIDER: S-EPMC11893308 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature