ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance.

ABSTRACT:

Objective

Regulatory T cells (Tregs) are essential in maintaining immune tolerance and controlling inflammation. Treg stability relies on transcriptional and post-translational mechanisms, including histone acetylation at the Foxp3 locus and FoxP3 protein acetylation. Additionally, Tregs depend on specific metabolic programs for differentiation, yet the underlying molecular mechanisms remain elusive. We aimed to investigate the role of acetyl-CoA carboxylase 1 (ACC1) in the differentiation, stability, and function of regulatory T cells (Tregs).

Methods

We used either T cell-specific ACC1 knockout mice or ACC1 inhibition via a pharmacological agent to examine the effects on Treg differentiation and stability. The impact of ACC1 inhibition on Treg function was assessed in vivo

SUBMITTER: Stuve P 

PROVIDER: S-EPMC11893314 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature