Composite score of PD-1 ^<b>+</b> CD8 ^<b>+</b> tumor-infiltrating lymphocytes and CD57 ^<b>+</b> CD8 ^<b>+</b> tumor ascites lymphocytes is associated with prognosis and tumor immune microenvironment of patients with advanced high-grade serous ovarian cancer.

ABSTRACT:

Objective

The expression of programmed death 1 (PD-1) on CD8⁺ T cells is associated with their activation and exhaustion, while CD57 serves as a senescence marker. The impact of PD-1⁺ and CD57⁺CD8⁺ T cells on the prognosis of patients with advanced high-grade serous ovarian cancer (HGSOC) remain unclear.

Methods

We assessed the percentages of PD-1⁺ and CD57⁺CD8⁺ T cells in tumor-infiltrating lymphocytes (TILs, n=85) and tumor ascites lymphocytes (TALs, n=87) using flow cytometry. The optimal cutoffs for these markers in TILs and TALs were determined through the log-rank maximization method. Gene expression analysis elucidated the tumor immune microenvironment (TIME, n=36).

Results

Patients wi

SUBMITTER: He T 

PROVIDER: S-EPMC11893342 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature