Pharmacokinetics and pharmacodynamics of insulin lispro 25 versus the original preparation (Humalog^®25) in Chinese healthy male volunteers.

ABSTRACT: Background: There are approximately 537 million adults with diabetes worldwide, and insulin still plays an important role in its treatment. However, the long-term use of insulin imposes a significant financial burden on patients. This study aims to explore the pharmacokinetic (PK)/ pharmacodynamic (PD) parameters of generic premixed insulin lispro 25 (25% insulin lispro and 75% protamine zinc lispro) and evaluate the bio-equivalence between generic and brand-name preparations to reduce medical costs while ensuring the effectiveness and safety of treatment. Research design and method: This is a single-center, randomized, open-label, two-period, crossover study. This study recruited 52 healthy volunteers and randomly divided them into two sequences to receive either the test (T

SUBMITTER: Zhu M 

PROVIDER: S-EPMC11893401 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature