PKR modulates sterile systemic inflammation-triggered neuroinflammation and brain glucose metabolism disturbances.

ABSTRACT: Sterile systemic inflammation may contribute to neuroinflammation and accelerate the progression of neurodegenerative diseases. The double-stranded RNA-dependent protein kinase (PKR) is a key signaling molecule that regulates immune responses by regulating macrophage activation, various inflammatory pathways, and inflammasome formation. This study aims to study the role of PKR in regulating sterile systemic inflammation-triggered neuroinflammation and cognitive dysfunctions. Here, the laparotomy mouse model was used to study neuroimmune responses triggered by sterile systemic inflammation. Our study revealed that genetic deletion of PKR in mice potently attenuated the laparotomy-induced peripheral and neural inflammation and cognitive deficits. Furthermore, intracerebroventricular injectio

SUBMITTER: Cheng WY 

PROVIDER: S-EPMC11893411 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature