Causal inference of inflammatory proteins in infertility: a Mendelian randomization study.

ABSTRACT:

Background

Infertility affects 8-12% of couples globally, manifesting as a complex reproductive disorder with varied causes, negatively impacting emotional, physical, and social well-being. Inflammation is implicated in many diseases, including male and female infertility.

Methods

This study employed Mendelian randomization (MR) with two-sample, bidirectional, and mediation approaches to explore the relationship between circulating inflammatory proteins and infertility. Causal analysis was conducted using inverse variance-weighted (IVW) and MR-Egger regression, supplemented by enrichment analysis, protein-protein interaction (PPI) network exploration, and drug signature analysis.

Results

Our findings identified a significant positive correlation between C-X-C motif ch

SUBMITTER: Chen P 

PROVIDER: S-EPMC11893426 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature